Molecular Systems Biology Peer Review Process File © European Molecular Biology Organization A chemical-genetic interaction map of small molecules using high-throughput imaging in cancer cells

Thank you again for submitting your work to Molecular Systems Biology. We have now heard back from two of the three referees who agreed to evaluate your manuscript. Rather than delaying the process further, I prefer to make a recommendation now with the two available reports. As you will see from the reports below, the referees find the topic of your study of potential interest. They raise, however, several concerns, which should be convincingly addressed in a revision of the manuscript. The recommendations provided by the reviewers are very clear and refer to the need to tone down some of the claims and to clarify several aspects of the study.